Evidence-first health & aging science Newsletter
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Longevity & Aging

Biological age & clocks

Close view of an older woman's ear and jaw, with grey hair tied back and a large drop earring.
News

Worse hearing loss tracked with higher death rates in 64,000 adults across four countries

Oct 21, 2026

An older woman in glasses reads a small product at a shop counter beside a laptop while an assistant faces her.
News

Over-the-counter hearing aids worked better for older adults with a doctor's or audiologist's help

Oct 19, 2026

An older couple seen from behind stand at a pedestrian crossing on a sunny city street lined with old buildings.
News

Later generations of Europeans over 50 had more physical and mental capacity, with ever smaller gains

Oct 16, 2026

A hospital procedure room with monitors and equipment around a draped table, and staff in blue scrubs and caps seen from behind.
News

Ablation for atrial fibrillation did not clearly beat a sham on quality of life in a 262-patient trial

Oct 9, 2026

A young woman stands behind a seated older man with her arms around his shoulders, his hand resting on hers, in a kitchen.
Explainer

Does caregiving shorten life? What studies since 1999 show about the health of family caregivers

Oct 9, 2026

Small anatomical models of a heart, lungs, intestines and a pair of kidneys laid out with wooden blocks on a pale surface.
News

Kidney transplant's survival edge over dialysis narrowed for older patients given higher-risk donor organs

Oct 9, 2026

The hands of a person in a white coat hold printed forms and a pen.
News

Five-session prostate radiotherapy eased bowel side effects, but relapse on blood tests was more common

Oct 9, 2026

A clinician in a white coat and blue gloves holds the upper arm of a girl standing in a bright room.
Explainer

Chickenpox vaccine and shingles: cases are falling in young adults and rising from age 35

Oct 6, 2026

A person in a pink sweater gestures with open hands while talking to a clinician in a white coat who holds a clipboard; neither face is shown.
Explainer

Early-onset cancer explained: which cancers are rising in adults under 50, and what is known about why

Oct 6, 2026

A woman sits bent forward on a treatment table while a therapist presses a hand against her lower back.
News

Women report more pain than men at all 11 body sites in a study of 6.1 million people in 118 countries

Oct 6, 2026

A hand resting on a wooden cane, held by a person in a long red coat whose face is not shown.
News

Wealth gap in aging: the poorest 60-year-olds in England walked as slowly as the richest 75-year-olds

Oct 4, 2026

An older couple in shorts, seen from behind, walking along a seaside promenade lined with lamp posts.
Explainer

Why women live longer than men: the gap held through famines, epidemics and slavery in seven populations

Oct 4, 2026

The facade of a concrete apartment block with rows of windows and enclosed balconies.
News

Childhood disadvantage was linked to higher adult death rates in a review of 102 studies, 8.5 million people

Oct 1, 2026

A smiling mother holding a toddler on her lap while writing at a table.
News

Cash gifts to low-income mothers slowed a DNA marker of aging pace in their young children

Sep 29, 2026

A person measuring their waist with a tape measure, shown close up
News

A blood marker of long-term inflammation went with 43% higher heart risk, in UK Biobank data

Sep 23, 2026

Two hourglasses side by side on a white surface, one with pale sand and one with dark
News

Biological aging clocks diverged between women and men across 15 organ systems

Sep 23, 2026

Gloved hands holding a rack of blood sample tubes with red and purple caps
News

High lipoprotein(a) raised heart risk as much after 70 as before, in 103,341 Danes aged 20 to 100

Sep 22, 2026

An older doctor with a gray beard and glasses, a stethoscope around the neck, looking down at a desk
News

Silent artery plaque turned up in 57% of 16,808 adults with no heart disease, and in some in their 20s

Sep 22, 2026

An older adult in a knit sweater sorting tablets from blister packs into a weekly pill organizer at a round table
News

Statins in healthy over-70s cut heart attacks and strokes by 30% but did not extend disability-free life

Sep 22, 2026

A woman in workout clothes ties a shoelace on park steps beside a rolled yoga mat
News

Regular exercise went with fewer new cases of bladder leakage after 50, in 11,126 adults in three countries

Sep 22, 2026

A woman brushing her teeth at a bathroom sink, her reflection in the mirror
Explainer

Tongue and interdental cleaning went with lower death rates in 9,676 older Japanese adults

Sep 21, 2026

A researcher in safety goggles looking into a microscope
News

Y chromosome loss deepened the closer tissue sat to a tumor, across 1,000 samples from 405 men

Sep 20, 2026

A small brown mouse crouched on a mossy stone
News

Aging hearts lose their drainage vessels, and in mice that loss helped drive inflammation

Sep 17, 2026

An illustration of a DNA double helix made of green stems, leaves and pink flowers
News

A gene variant linked to long life kept brain blood vessel support cells healthier in mice and lab cells

Sep 17, 2026

A small brown bat clinging head-down to a metal hinge
News

Long-lived bats carry genetic changes that may link their resistance to cancer and to viruses

Sep 17, 2026

A gloved hand holding two tubes of blood against a beige background
News

Some epigenetic aging clocks respond to treatment far more than others, a pooled analysis of 51 studies finds

Sep 17, 2026

A white mouse standing on its hind legs against a black background
News

Semaglutide started late in life extended lifespan in female mice and matched calorie restriction

Sep 16, 2026

Two filled blood collection tubes, one red-capped and one lavender-capped, beside safety goggles on a blue drape
News

Hemoglobin just over the anemia cutoff linked to more deaths in half a million UK adults

Sep 14, 2026

Racks of blood sample tubes on a laboratory bench beside a computer
News

Blood mutations that accumulate with age tracked faster progression to advanced heart and kidney disease

Sep 8, 2026

An older man with a grey beard holding an inhaler, his face out of focus behind it
News

COPD patients left hospital without guideline inhalers in more than one in five cases

Sep 8, 2026

A clinician pointing at a chest X-ray held up to the light
News

Lung damage found by accident on a scan tracked 54% higher death risk

Sep 6, 2026

An older man holding an inhaler toward the camera
News

An old antibiotic beat a newer drug at preventing COPD flare-ups, 17% fewer

Sep 4, 2026

A clinician fitting a hearing aid behind an older woman's ear
News

Two hearing aids beat one in the first trial to test it, by a margin the authors won't call meaningful

Sep 4, 2026

An elderly woman being pushed in a wheelchair along a bright care home corridor
News

The high-dose flu shot cut flu hospital admissions by 31% in French care homes, average age 88

Aug 30, 2026

A dietitian with a laptop talking across a kitchen counter to an older woman seen from behind
Explainer

Redesigning meals raised older adults' protein intake by 12 grams a day, and counseling did the work

Aug 26, 2026

Four older women sitting round a white table with books, coffee cups and reading glasses, mid-conversation
News

Social participation tracked 22% lower death risk in older adults across 25 cohort studies

Aug 26, 2026

An older person's hands filling a weekly pill organizer beside loose tablets and blister packs
News

Pharmacist deprescribing cut 2.5 drugs per patient, but six-month totals held steady

Aug 17, 2026

An older man in a dark coat walking with a cane along a park path, other people behind him
News

Physical and mental decline began years before a first fall, not after it

Aug 14, 2026

An overhead arrangement of small bowls and measuring spoons holding beans, lentils, grains, seeds and walnuts
News

Plant protein tracked lower death rates, animal did not

Aug 8, 2026

A middle-aged woman in a coat walking past shopfronts
News

One in three healthy middle-aged adults was prefrail

Aug 6, 2026

An older woman talking with a companion over coffee among green plants
News

Habits predicted healthy aging; blood markers did not

Aug 6, 2026

Bunches of dark red grapes hanging on the vine among green leaves
verdict

Resveratrol: uses, evidence, dosing and safety

Aug 6, 2026

White powder being weighed on an antique brass apothecary balance
verdict

NMN and NR: uses, evidence, dosing and safety

Aug 5, 2026

An older man sitting alone at a table by a bright window
News

Younger generations are aging faster, and cancer tracks it

Aug 4, 2026

A person's legs in running shoes climbing a flight of stone steps
News

Metformin added nothing to exercise in older adults

Aug 4, 2026

A black and white close-up of an elderly hand resting on a chair arm
News

Fix everything but DNA damage and you get 156 years

Aug 3, 2026

A white cup filled with sugar cubes on a pink background, seen from above
News

Rationed sugar in infancy tracked younger biological age

Aug 3, 2026

A white tablet bottle on its side with round white pills spilling onto blue
News

Daily aspirin did nothing for healthspan in 19,114 older adults

Aug 2, 2026

A clinician examining moles on the back of an older patient
News

A missed melanoma cost patients 8.2 years of life on average

Aug 2, 2026

An older woman wearing headphones and looking at a phone screen
News

Hearing loss tracked frailty, but not in hearing aid users

Aug 1, 2026

A gloved researcher using a multichannel pipette over a sample tray in a laboratory
News

Smoking and waist size beat every epigenetic clock tested

Jul 31, 2026

A glass ashtray of spent cigarette butts with one still burning
News

Longevity genes helped. Not smoking helped far more.

Jul 31, 2026

A woman in her forties looking away, lit against a dark green background
News

US women reach menopause at 50. One in 10 gets there early.

Jul 31, 2026

A scientist working at a laboratory bench lined with instruments
News

A blood metabolite clock tracked death risk and frailty

Jul 31, 2026

A woman looking out through a window in daylight, city street behind the glass
News

Social disadvantage tracked with three fewer reproductive years

Jul 29, 2026

Fresh chanterelle mushrooms and rosemary sprigs on a wooden board
News

Ergothioneine topped 991 blood markers of brain health

Jul 27, 2026

An older woman walking along a park path with a walking pole
News

Gut bacteria tracked with frailty in 2,081 older women

Jul 26, 2026

A gloved scientist pipetting a red sample into a rack of test tubes
News

Proteomic aging clocks didn't beat lifestyle questions

Jul 26, 2026

A gloved scientist adjusting a slide on a laboratory microscope
News

Sleep and exercise curbed mutant blood stem cells

Jul 25, 2026

A researcher in a white coat loading a sample into a laboratory centrifuge
News

Organ age clocks: a blood test for 40 cell types

Jul 23, 2026

A semaglutide injection pen resting on a surface
News

Semaglutide slowed biological aging clocks in a small trial

Jul 17, 2026

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