Heart & Metabolic

GLP-1 & weight-loss drugs

Hands holding a blister pack of white capsules, with a breakfast plate on the table behind.

Safiglipron, a GLP-1 pill with no fasting rules, matched or beat dapagliflozin on blood sugar

Oct 21, 2026

A woman seen from behind at a kitchen table eats with chopsticks while on a video call on a laptop.

Women weighed six months into an online tirzepatide program had lost 15.5%; the study had no comparison group

Oct 20, 2026

A hand holds up a thin syringe with a fine needle against a plain bright blue background.

Petrelintide users lost about 8% to 10% of body weight in 28 weeks in a phase 2 trial funded by its maker

Oct 16, 2026

A blood glucose meter, two syringes, a test strip and a blue ribbon laid out on a pale blue surface.

Survodutide cut body weight by 8% to 10% in people with type 2 diabetes, and most had gut side effects

Oct 12, 2026

A teenager in a green sweatshirt sits with hands clasped while a clinician in teal scrubs, gloves and a face mask talks and gestures.

Obesity drugs for children: what a new WHO guideline says and what trials in under-12s and teenagers show

Oct 9, 2026

A glass of water with a few orange tablets beside it on a pink surface.

Orforglipron pill was no worse for the heart than insulin in a 2,749-person diabetes safety trial

Oct 9, 2026

A person in a sports top and dark leggings stands against a brick wall holding a tape measure out from the waist, face out of frame.

Top-dose retatrutide cut body weight 25% over 80 weeks in a 2,339-person trial, with gut side effects common

Oct 9, 2026

A smiling boy and an adult sharing a meal at an outdoor table with fruit and juice.

GLP-1 drugs in teens: 1 in 6 had a nutrient deficiency diagnosed within a year

Sep 26, 2026

Older hands holding an inhaler and a spacer outdoors

GLP-1 drugs went with 12% fewer asthma attacks than a rival diabetes drug, in 100,746 patients

Sep 23, 2026

The control panel and screen of an ultrasound machine in a clinic

Tirzepatide and semaglutide showed the same serious liver outcomes over about 17 months

Sep 23, 2026

A doctor listening to a child's chest with a stethoscope at a desk

GLP-1 prescriptions for children aged 8 to 11 rose 310-fold since 2019, in records of 3.5 million kids

Sep 23, 2026

A blood glucose meter, two syringes, tablets and a lancet pen laid out on a purple background

Heart benefit of GLP-1 drugs faded after people stopped, in 333,687 US veterans with type 2 diabetes

Sep 23, 2026

A gray rat eating a piece of food between two white and patched rats

Combining two next-generation weight-loss drugs beat either one alone in obese rats

Sep 17, 2026

An older couple walking arm in arm along a city street

Semaglutide and tirzepatide tracked half the femoral fractures of another diabetes drug

Sep 1, 2026

A close-up of an eye lit by a narrow band of light, iris and lashes in sharp detail

Sudden vision loss hit 3 more GLP-1 users per 10,000 over 18 months than two rival diabetes drugs

Aug 28, 2026

Two small white tablets on a plain pink background

An oral GLP-1 pill cut weight 9% in a phase 2 trial

Aug 4, 2026

A woman running a hand through her hair and looking toward the camera

GLP-1 drugs carried higher hair loss risk than two rivals

Aug 2, 2026

Two clinicians examining spine X-rays displayed on a lightbox

GLP-1 drugs tracked with fewer fractures, but only with diabetes

Jul 29, 2026

A patient in a hospital gown standing at a clinic weighing scale

Mazdutide took off 16.7% of body weight in a phase 3 trial

Jul 29, 2026

Two teenagers playing on an outdoor running track

Weight-loss drugs worked better with lifestyle, not without

Jul 28, 2026

A person sitting on the edge of a bed with hands on their knees

Stopping GLP-1 drugs tracked with more anxiety after

Jul 28, 2026

Overlapping blister packs holding many different coloured tablets and capsules

Semaglutide led the field for antipsychotic weight gain

Jul 27, 2026

Masked surgeons working under theatre lights during an operation

Bariatric surgery cost less downstream than GLP-1 drugs

Jul 27, 2026

A hand operating the control panel of an ultrasound scanner

Survodutide cleared liver fat in 84% of patients

Jul 27, 2026

A single white oval tablet on a pale blue background

Oral GLP-1 pill elecoglipron hit 10% weight loss in a trial

Jul 26, 2026

A person holding a blue medical injection pen indoors

Apitegromab kept muscle on during tirzepatide weight loss

Jul 25, 2026