Evidence-first health & aging science Newsletter
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Longevity & Aging

Healthspan & frailty

Close view of an older woman's ear and jaw, with grey hair tied back and a large drop earring.
News

Worse hearing loss tracked with higher death rates in 64,000 adults across four countries

Oct 21, 2026

An older couple seen from behind stand at a pedestrian crossing on a sunny city street lined with old buildings.
News

Later generations of Europeans over 50 had more physical and mental capacity, with ever smaller gains

Oct 16, 2026

A person in a white shirt, seen from behind, sitting alone on a bench facing the sea, with lighthouses in the distance.
News

Loneliness and isolation tied to up to 5.8 fewer years free of depression or anxiety in 277,489 adults

Oct 4, 2026

The empty wooden benches of a sauna lit by warm lights.
Explainer

Are saunas good for your heart? What the research shows

Sep 29, 2026

A woman brushing her teeth at a bathroom sink, her reflection in the mirror
Explainer

Tongue and interdental cleaning went with lower death rates in 9,676 older Japanese adults

Sep 21, 2026

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News

Some epigenetic aging clocks respond to treatment far more than others, a pooled analysis of 51 studies finds

Sep 17, 2026

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News

Semaglutide started late in life extended lifespan in female mice and matched calorie restriction

Sep 16, 2026

An overhead view of a clinician holding a pill bottle and pen over a clipboard, across a desk from an older patient's hands
News

Frail kidney patients had triple the odds of cognitive impairment across 129,868 people

Aug 26, 2026

An older person's hands filling a weekly pill organizer beside loose tablets and blister packs
News

Pharmacist deprescribing cut 2.5 drugs per patient, but six-month totals held steady

Aug 17, 2026

A middle-aged woman in a coat walking past shopfronts
News

One in three healthy middle-aged adults was prefrail

Aug 6, 2026

White powder being weighed on an antique brass apothecary balance
verdict

NMN and NR: uses, evidence, dosing and safety

Aug 5, 2026

An older man sitting alone at a table by a bright window
News

Younger generations are aging faster, and cancer tracks it

Aug 4, 2026

A black and white close-up of an elderly hand resting on a chair arm
News

Fix everything but DNA damage and you get 156 years

Aug 3, 2026

A white cup filled with sugar cubes on a pink background, seen from above
News

Rationed sugar in infancy tracked younger biological age

Aug 3, 2026

A white tablet bottle on its side with round white pills spilling onto blue
News

Daily aspirin did nothing for healthspan in 19,114 older adults

Aug 2, 2026

A gloved researcher using a multichannel pipette over a sample tray in a laboratory
News

Smoking and waist size beat every epigenetic clock tested

Jul 31, 2026

A glass ashtray of spent cigarette butts with one still burning
News

Longevity genes helped. Not smoking helped far more.

Jul 31, 2026

A woman in her forties looking away, lit against a dark green background
News

US women reach menopause at 50. One in 10 gets there early.

Jul 31, 2026

A scientist working at a laboratory bench lined with instruments
News

A blood metabolite clock tracked death risk and frailty

Jul 31, 2026

An older couple in a bright kitchen with pears, oranges and lemons on the counter
News

Following the official diet advice tracked with a firmer grip

Jul 29, 2026

A gloved scientist pipetting a red sample into a rack of test tubes
News

Proteomic aging clocks didn't beat lifestyle questions

Jul 26, 2026

A researcher in a white coat loading a sample into a laboratory centrifuge
News

Organ age clocks: a blood test for 40 cell types

Jul 23, 2026

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