verdict Phosphatidylcholine: uses, evidence, dosing and safety
Phosphatidylcholine is a major phospholipid in cell membranes and the main dietary form of choline. Its best-studied use is as an add-on in ulcerative colitis, where small early trials looked promising but the largest trials did not confirm a lasting benefit. Evidence for memory, fatty liver and most other uses is weak, the largest liver trial (in people with alcohol-related liver disease) was negative, and because gut bacteria turn its choline into TMAO, high doses carry a debated heart concern rather than a benefit.
Jul 22, 2026
